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KMID : 0895820080180030051
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Journal of Oriental Rehabilitation Medicine
2008 Volume.18 No. 3 p.51 ~ p.65
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The Inhibitory Effects of Soongijeseub-bang(Shunqichushi-fang) on the Obese-mice Caused by High Fat Diet
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Lee Woo-Yeol
Yoon Il-Ji
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Abstract
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Objectives :In oreder to investigate the effects of Soongijeseub-bang(Shunqichushi-fang)(here in after referred to SJB) on the obese gene and obese inhibitory, on C57BL/6 mice were induced by high fat diet.
Methods :C57BL/6 mice were divided into three groups(normal, high fat diet with control, high fat diet with SJB extract) and fed for 15 weeks. And observed that, body weight change, final increase of body weight, the weight change of the adipocytes, the level change of ALT, AST, creatinine, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, NEFA, glucose, the expression of β3AR, leptin, and TNF-α gene in primary adipocytes and adipocytes tissue.
Results :The following results were obtained in this study. 1. SJB 500 ㎎/㎏ extract group showed considerable decrease in weight, the final increase of weight and the amount of adipocyte in weight. 2. All experimental group showed that the amount of ALT, AST, total cholesterol, LDL-cholesterol, triglyceride and NEFA were decreased considerably. SJB 500 ㎎/㎏ extract group showed the amount of HDL-cholesterol and leptin were increased considerably. 3. All experimental group showed that the revelation of β3AR in primary adipose cell and 3T3-L1 cell were increased considerably, and that the revelation of leptin in primary adipose cell and 3T3-L1 cell were decreased considerably. SJB 100 ㎕/㎖ extract group showed that the revelation of TNF-α were decreased considerably. 4. SJB 500 ㎎/㎏ extract group showed that the size of adipocyte in adipocytes tissue were decreased. 5. All experimental group showed that the adipose vacuoles in liver tissue were decreased considerably.
Conclusion :Comparison of the results for this study showed that SJB is effective on obesity care and has obese-inhibitory effects in obese mouse induced by high fat diet. So it is respected that the clinical application of SJB can help the treatment of obesity.
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KEYWORD
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Soongijeseub-bang(Shunqichushi-fang)(SJB), Obese gene, Obese inhibitory, Adipocyte, Liver tissue
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